11-17-2007, 06:35 PM
Summary. Background: Evidence has accumulated that in both acutely ill and recovered patients with either anorexia or bulimia nervosa circulating
leptin levels (LL) are lower than in controls matched for body mass index (BMI; kg/m2). It is unknown if these lower leptin levels represent a state or trait marker. Aim of the study: We aimed to confirm the lowered leptin levels in eating disordered females and to identify underlying mechanisms. Methods: We screened 181 female students of the nutritional sciences for eating disorders with the respective module of the M-Composite
International Diagnostic Interview and the Cognitive Restraint scale of the Three Factor Eating Questionnaire. The physical
assessment included determinations of BMI, body composition and LL. Each case fulfilling lifetime DSM-IV criteria for an eating
disorder was BMI matched to two controls. We used a multivariate mixed regression model to evaluate if the observed difference
in lg10-leptin level between cases and controls is actually due to the influence of restrained eating and/or previous weight loss
after adjustment for BMI and percent body fat. Results: In accordance with our hypothesis the 32 (17.7 %) cases had a lower serum lg10-leptin level than the 64 BMI matched controls (one-sided p < 0.001). We were not able to detect an influence of restrained
eating or previous weight loss. Conclusions: We confirm that females with a lifetime history of an eating disorder have lower LL. We were not able to identify an underlying
mechanism. Similar to most previous studies we found a high rate of eating disorders among female students of nutritional
sciences.
Content TypeJournal Article
JournalEuropean Journal of NutritionOnline ISSN 1436-6215Print ISSN 1436-6207
Journal VolumeVolume 42
Journal IssueVolume 42, Number 3 / June, 2003 (Source: European Journal of Nutrition)
Posted on Wed, 05 Sep 2007 18:39:03 +0100 at http://www.springerlink.com/content/r526071w77344881/
Author: European Journal of Nutrition
Comments: http://www.medworm.com/rss/comments.php?id=845577
leptin levels (LL) are lower than in controls matched for body mass index (BMI; kg/m2). It is unknown if these lower leptin levels represent a state or trait marker. Aim of the study: We aimed to confirm the lowered leptin levels in eating disordered females and to identify underlying mechanisms. Methods: We screened 181 female students of the nutritional sciences for eating disorders with the respective module of the M-Composite
International Diagnostic Interview and the Cognitive Restraint scale of the Three Factor Eating Questionnaire. The physical
assessment included determinations of BMI, body composition and LL. Each case fulfilling lifetime DSM-IV criteria for an eating
disorder was BMI matched to two controls. We used a multivariate mixed regression model to evaluate if the observed difference
in lg10-leptin level between cases and controls is actually due to the influence of restrained eating and/or previous weight loss
after adjustment for BMI and percent body fat. Results: In accordance with our hypothesis the 32 (17.7 %) cases had a lower serum lg10-leptin level than the 64 BMI matched controls (one-sided p < 0.001). We were not able to detect an influence of restrained
eating or previous weight loss. Conclusions: We confirm that females with a lifetime history of an eating disorder have lower LL. We were not able to identify an underlying
mechanism. Similar to most previous studies we found a high rate of eating disorders among female students of nutritional
sciences.
Content TypeJournal Article
JournalEuropean Journal of NutritionOnline ISSN 1436-6215Print ISSN 1436-6207
Journal VolumeVolume 42
Journal IssueVolume 42, Number 3 / June, 2003 (Source: European Journal of Nutrition)
Posted on Wed, 05 Sep 2007 18:39:03 +0100 at http://www.springerlink.com/content/r526071w77344881/
Author: European Journal of Nutrition
Comments: http://www.medworm.com/rss/comments.php?id=845577